Talk:Oxycodone

Roxane Labs or Xanodyne?

The page lists Roxane Laboratories as the distributor of Roxicodone in the U.S. However, http://www.xanodyne.com/products-other.asp would indicate that this trademark would belong to Xanodyne Pharmaceuticals. I visited Roxane Labs' site and they don't seem to mention anything about Roxicodone.

an import ref, but not in wiki

In 2007, the profits were just a few billion. As of July 2016, more than $31 billion from OxyContin, the nation's bestselling painkiller.

The OxyContin profits have added the family to the Forbes: The $14 Billion Newcomer to Forbes 2015 List of Richest U.S. Families — Preceding unsigned comment added by 87.218.11.176 (talk • contribs)

References

Oral bioavailability

Oral bioavailability of oxycodone is 50-59% mean; 30-87% range

Note that the 87% figure was from a single 6 person study funded by the drug company. Several independent studies have verified that the bioavailability is closer to 59%. I am Lorne, from Blue Light. Somewhere on that site are numerous references proving oxycodone BA% both oral and intranasal, is at or just over 50%. 87% is nonsense. Editing is difficult from my phone, someone please edit and fix this

https://link.springer.com/article/10.1007/s00228-012-1267-9.

Here is a single reference for a 59% figure, though it is in the elderly, there are others.

Please, we need to really fix this, and put the intranasal mean 48% figure. Come on, our info needs to be thoughoufh and correct

Thank You 2600:1005:B05C:57D1:0:53:4136:3201 (talk) 20:32, 23 June 2022 (UTC)

Media

Should this article include a reference to the Netflix series Painkiller? "... a fictionalized telling of real events, explores some of the origins and aftermath of the opioid crisis in America, highlighting the stories of perpetrators, victims, and truth-seekers whose lives are forever altered by the invention of OxyContin. Painkiller, premieres August 10." Phyllostachys (talk) 10:59, 20 August 2023 (UTC)

What this article should include is the CDC graph showing deaths by various opioids that shows the opioid death crisis only started because of the Obama Administration's policy change regarding OxyContin in September 2013 and the subsequent DEA crackdown on the pill mills in 2014. But that will never happen. It's much easier to blame Purdue for everything.

I can't believe how well this ridiculous propaganda campaign, that this is all Purdue being uniquely evil, and that Oxycontin is a uniquely danger, has worked over the last 5 years.

As is said in this article: "Reformulated OxyContin is causing some recreational users to change to heroin, which is cheaper and easier to obtain". The government's own researchers knew the disaster the oxy crackdown would cause but they were ignored.

With me quoting that line here, it's probably going to be purged from the website, just like the study it links to got purged from the internet. Wonder why that may be.

The opioid death crisis is completely of the US Government's making and judging by all these ridiculous documentaries, they'll probably get away with it forever.

https://www.cdc.gov/opioids/data/analysis-resources.html

2010: Forced "Abuse Resistant" variant of Oxy rolled out. Heroin Epidemic.

2013/2014: Crackdown on the pill mills. Fentanyl Epidemic. TheJesterKing (talk) 19:39, 9 November 2023 (UTC)

I think the matter is an odd one - I have heard all of the arguments - it needs a prescriber - and Physicians were part of the issue - surely. aggressive marketing and actively prescribing - are two separate issues - the article really in my mind is about the compound - it is still prescribed very often - much more thoughtfully, and in a more regulated manner - but it is a super common med. Oddly heroin has been used medically in the UK for decades - they just call it diamorphine - I guess it sounds better -- Dr. BeingObjective (talk) 19:54, 9 November 2023 (UTC)

The problem I have is recommendations like the one I responded to wanting to put in references to recent shows/documentaries that completely ignore what caused the opioid crisis to begin with.

On that CDC resources page, scroll down and look at the graph that shows the 3 "waves" of overdose deaths. Wave 2 is in 2010. Notice that before that heroin deaths were flat. In 2010 the government forced Purdue to reformulate Oxy to make it harder to "abuse".

Here's the National Bureau of Economic Research on how that caused a heroin epidemic, there are many studies like this one from 2018, but the government was warned before the forced reformulation the heroin death surge would happen: https://www.nber.org/system/files/working_papers/w24475/w24475.pdf

I knew people who worked with pain doctors back then and even with the reformulation, at least anecdotally, doctors between the years 2010 and 2013 started pushing fentanyl over oxy even though fentanyl has a vastly higher risk of overdose because of the microgram scale LD/50 and generally horrific side effects. Those people became addicted to fentanyl, not Oxy.

Recreational use of fentanyl was basically unheard of until late 2013. Look at the CDC graph on the 3rd wave. What does that line up with? The Obama admin's policy change regarding oxy and the first pain doctor visits from the DEA.

A large section of this article is devoted to the supposition that over prescription of Oxycodone is responsible for the opioid nightmare we're living in. It isn't, and I'm asserting this as fact. The opioid crisis was manufactured by the Obama administration by 2 decision against oxy, one in 2010 and the other in 2013. I'll leave you to decide whether this was incompetence or something darker. I'm sick of this absurd narrative around Purdue because it buries the deadliest policy decision in American history. Messing with the oxy formulation and then cracking down on pain doctors has killed more Americans than the Civil War and no one has noticed the government's role. TheJesterKing (talk) 16:38, 10 November 2023 (UTC)

Being blunt - it is not something I debate - in any forum. There is no one single cause - I do think clinicians get a bit of a pass by the media.

This is just part of an article - oxycodone is still prescribed - a lot - even now - it is very useful. Now docs are audited, monitored - but, they are not going to see a patient in pain - morphine sulfate, oxycodone, hydrocodone, buprenorphine, Vicodin - fentanyl patches - all very commonly prescribed. BeingObjective (talk) 16:48, 10 November 2023 (UTC)

What I'm laying out here is, on all of Wikipedia, only mentioned in one single sentence in this article, hence why I came in here to discuss it. I don't think clinicians get a pass at all in the media, what I'm saying is the government getting a pass in the media.

Look at the CDC's own graph. Over prescribing got people Addicted to opioids, but they weren't dying at a rate of 120,000 per year. Also, for those who took their oxy-related pills recreationally, as in "abused" them (whatever that means), the ones mixed with acetaminophen cause problems when mixed with alcohol, which, when people take other recreational drugs, they're usually also drinking.

"Now docs are audited, monitored". They are, by the DEA, which violates the DEA's charter. The DEA has no more business even interacting with doctors than the CIA would have doing spycraft inside the borders of the United States.

Why I'm laying all this out is to see what the community might think if I countered the singular focus on over-prescription and Purdue causing the opioid crisis, and I used actual peer reviewed studies, whether my edits would be immediately nuked.

From what I've gathered, any edit I make on that section of this article would get deleted, so I won't waste my time, but at least this talk page can archive legitimate disagreements with the opioid crisis part of the article. TheJesterKing (talk) 18:26, 10 November 2023 (UTC)